Clinical immunology.

Clinical Immunology

The purpose of this mini-review is to update the nonspecialist reader on the basic immunological mechanisms which underlie an effective immune response and the clinical disorders which results when the processes are deficient or disordered. The basic science description is, of necessity limited in scope and detail. Further explanation of the basic cellular and molecular mechanisms involved in i...

Clinical immunology.

Allergy, Asthma & Clinical Immunology

Objective: Molecular regulation of inflammation, especially, the role of effector cells in NADPH oxidase-mediated redox reactions for producing O2 (superoxide anion) is a critical step. This study explores the roles of macrophages and neutrophils and their cross-talk with extra-cellular matrix components in the light of the role essayed by T cells. Materials and Methods and Treatment: To clarif...

Allergy, Asthma & Clinical Immunology

Background: Class-I MHC-restricted T cell-associated molecule (CRTAM) is a protein expressed by activated natural killer T (NKT) cells, natural killer (NK) cells, CD8 T cells, and certain CD4 T lymphocytes. It is also expressed in Purkinje neurons and epithelial cells. However, no studies have examined the expression of CRTAM in peripheral blood cells during homeostasis or disease. Therefore, w...

Allergy, Asthma & Clinical Immunology

Background: Basophils are important effectors cells in allergic rhinitis (AR) since they are involved in immunoglobulin (Ig) E – mediated inflammation and in the release of pro-inflammatory mediators. Specific subcutaneous immunotherapy (SCIT) provides clear immunologic modulation in some immune cells, however its systemic effects on basophils are not well known. Methods: Peripheral blood (PB) ...